Warfarin skin necrosis mimicking calciphylaxis in a patient with secondary hyperparathyroidism undergoing peritoneal dialysis

Warfarin skin necrosis mimicking calciphylaxis in a patient with secondary hyperparathyroidism undergoing peritoneal dialysis

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Warfarin skin necrosis (WSN) is an infrequent complication of warfarin treatment and is characterized by painful ulcerative skin lesions that appear a few days after the start of Safety Key Clip warfarin treatment.Calciphylaxis also appears as painful skin lesions caused by tissue injury resulting from localized ischemia caused by calcification of small- to medium-sized vessels in patients with end-stage renal disease.We report on a patient who presented with painful skin ulcers on the lower extremities after the administration of warfarin after a valve operation.Calciphylaxis was considered first because of the host factors; eventually, the skin lesions were diagnosed as WSN by biopsy.

The skin lesions improved after warfarin discontinuation and short-term steroid therapy.Most patients with end-stage renal disease have some form of cardiovascular disease and some require temporary or continual warfarin treatment.It is important Side x Side Fridge to differentiate between WSN and calciphylaxis in patients with painful skin lesions.